Salcher, fresh from claiming bronze in the downhill and super-G events at the Pyeongchang 2018 Winter Paralympic Games, triumphed with a time of 1min 11.26sec at the Misanenga venue.
He is currently fourth in the overall rankings, but has a good chance to take the title with the top three not competing in Obersaxen.
Switzerland’s Robin Cuche finished second today in 1:12.00, while compatriot Thomas Pfyl came third in 1:13.46.
Vancouver 2010 silver medallist Melania Corradini was the fastest in the women’s super-G standing event with a time of 1:24.25.
The win extends the Italian’s dominance atop the overall rankings and moves her a step closer to the Europa Cup title.
Switzerland’s Bigna Schmidt took the silver medal in 1:26.92, while Spain’s Ursula Pueyo Marimon came away with the bronze in 1:28.19.
The women’s super-G sitting event was won by 26-year-old Ruth Hagspiel of Germany in 1:25.85.
She finished ahead of France’s Meije Bidault, who clocked a time of 1:33.72.
Two-time Paralympic champion Christoph Kunz of Switzerland continues to lead the overall men’s super-G sitting rankings after claiming gold in 1:12.35
Czech Republic’s Pavel Bambousek finished second today in 1:18.74, while Kunz’s compatriot Murat Pelit completed the top three in 1:19.89.
In the men’s visually impaired, France’s Thomas Civade and guide Fabien Chambost came first in 1:17.82.
Great Britain’s Michael Kear, guided by Louise Harrison, ended second in 1:30.82.
The super-combined races are due to be decided tomorrow.
The same five winners of today’s super-G events lead the way after run one.